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Running Mortality Syndrome (RMS) in Andhra Pradesh: Diagnostic Signs, Triggers & Biological Stabilization

Managing insidious daily mortalities between DOC 30 and 70 caused by viral-bacterial complexes and microsporidian triggers.

Published: 2026-10-10
11 min read
CAA Certified • ISO 9001:2015
100% Antibiotic-Free
Clinical Executive Summary: Running Mortality Syndrome (RMS) has haunted shrimp farmers across West Godavari and Krishna districts for over a decade. Characterized by continuous low-level daily mortalities without pathognomonic external lesions, learn how to stabilize affected ponds.
Farm Technician Print-Ready Protocol SheetPrint 1-page clinical protocol for pond supervisors & check tray stations.
తె
తెలుగు రైతుల క్లినికల్ గైడ్ (Telugu Farmer Advisory)

రొయ్యల రన్నింగ్ మోర్టాలిటీ సిండ్రోమ్ నివారణ (Running Mortality Syndrome - RMS)

(Running Mortality Syndrome (RMS))
చెరువులో గమనించాల్సిన ప్రధాన లక్షణాలు (Gross Symptoms):
  • 1DOC 35-65 మధ్య ప్రతిరోజూ 20 నుండి 100 వరకు రొయ్యలు నిరంతరం చనిపోవడం
  • 2రొయ్యల ఆకలి మందగించడం మరియు శరీర కండరాలు పారదర్శకత కోల్పోవడం
  • 3చెరువు అడుగున చనిపోయిన రొయ్యలు కనిపించడం
సిఫార్సు చేసిన 100% యాంటీబయాటిక్ రహిత బయో-ఇన్‌పుట్ చికిత్స (Protocol):
  • ✓నెక్స్ట్ విరో నిల్ (Next Viro Nill) ఎకరానికి 1.5 లీటర్లు ఉదయాన్నే నీటిలో వేయండి.
  • ✓మేతలో నెక్స్ట్ గట్ (Next Gut) ప్రోబయోటిక్ 15 మి.లీ/కిలో కలిపి రోగనిరోధక శక్తిని పెంచండి.
  • ✓చెరువులో ఏరియేషన్ పెంచండి మరియు ఫీడింగ్ పరిమాణాన్ని 30% తగ్గించండి.
సిఫార్సు చేసిన ఉత్పత్తి (Recommended):నెక్స్ట్ విరో నిల్ & నెక్స్ట్ గట్CAA ఆమోదం పొందిన శాస్త్రీయ బయో-ఇన్‌పుట్
వాట్సాప్ ద్వారా నిపుణులతో మాట్లాడండి8977656444
Interactive In-Article Clinical Tool

Pond Dosage & Biomass Calculator

Calibrated for: Running Mortality Syndrome (RMS)
Quick Acreage Presets:
Pond Surface Area1 Acres
≈ 4,047 m²
Average Water Depth4 Feet
≈ 1.2 Meters
Shrimp Size (ABW)14 g
Count: ≈ 71 pcs/kg
Stocking Density50 PL/m²
Survival: 75% assumed
Standing Biomass2,125 kg(21.3 Quintals)
Daily Feed Consumption77 kg/day(3.6% of body wt)
Pond Water Volume49.3 Lakh L(4,933.932 m³)
Recommended Dosage2.0 Litres / AcreNext Viro Nill & Next Gut Co-Administration
Application Method: Dilute with pond water and broadcast evenly across aerator plumes.
Optimal Timing: Morning application under bright sunlight with full aeration.
Need custom advice for your pond? Call Helpline: +91 8977656444
Order Next Viro Nill & Next Gut Co-AdministrationPond Doctor Diagnostic Tool
Institutional Benchmark & E-E-A-T Comparative Analysis

Next Farm Bio Sciences vs Institutional Standards

Comparative analysis against NFDB, ICAR-CIBA, and Chemical Practices for Running Mortality Syndrome (RMS).

CAA 2024 Gazette Compliant
Recommended Solution

Next Farm Bio Sciences

Targeted biological bio-inputs & competitive exclusion probiotics.

  • Potency: 10–50 Billion CFU/g multi-strain consortium
  • Antibiotics: 100% Zero. Pure biological enzymes
  • Clinical Window: 3–5 Day biological re-epithelialization
  • Export Compliance: 100% Pass (0.00 ppb residue guarantee)
Field-Proven in 4,200+ AP Ponds

NFDB Guidelines

National Fisheries Development Board standard Best Management Practices.

  • Focus: Biosecurity, SPF seed sourcing & liming
  • Therapeutics: Promotes natural disease avoidance
  • Limitation: General guidance without specific bio-inputs
  • Export Compliance: Fully compliant with national goals
Institutional Policy Framework

ICAR-CIBA Protocols

Central Institute of Brackishwater Aquaculture research advisories.

  • Research: Phytobiotics (EHP-Cura) & PCR diagnostics
  • Antibiotics: Strictly advises against chemical drugs
  • Limitation: Heavy reliance on centralized laboratory testing
  • Export Compliance: Scientific research aligned
Premier Research Institution

Chemical & Antibiotics

Banned chemical dips, OTC, Enrofloxacin, formalin.

  • Efficacy: Fails against intracellular spores (EHP)
  • Gut Impact: Destroys microvilli; triggers hepatopancreas necrosis
  • Legality: Banned under CAA Gazette; penal actions
  • Export Risk: 100% Export Rejection at EU/USFDA ports
High Economic Catastrophe Risk

1. Clinical Profile of Running Mortality Syndrome (RMS)

RMS typically strikes between DOC 35 and DOC 70. Unlike WSSV which wipes out a pond in 72 hours, RMS causes continuous daily losses of 20 to 100 dead shrimp per acre collected from feeding trays and pond corners every single morning.

Dissection reveals pale or empty guts, variable hepatopancreas shrinkage, and occasionally whitish musculature. Extensively investigated by CIBA, RMS is recognized as a multifactorial syndrome involving sub-clinical viral triggers compounded by secondary Vibrio and benthic toxicities.

2. Differential Diagnosis Table

Use this guide to distinguish RMS from acute epizootics:

Diagnostic FeatureRunning Mortality Syndrome (RMS)White Spot Syndrome Virus (WSSV)Acute Hepatopancreatic Necrosis (AHPND)
Onset WindowDOC 35 – 75 (Insidious)Any DOC (Acute)DOC 10 – 35 (Early mortality)
Daily Loss Pattern20 – 100 pcs/day ongoing100% loss within 48–72 hours50–90% loss within 4–6 days
Cuticle LesionsNone (clean shell)White circular calcified spotsSoft shell; empty gut
HepatopancreasSlightly pale or atrophiedNormal or pinkishPale, shrunken, totally non-functional

3. The 3-Step Biological Stabilization Regimen

Immediate Step 1: Broadcast Next Viro Nill @ 1.5 Litres per acre to suppress free-swimming pathogen reservoirs.

Step 2: Top-dress Next Gut @ 15 mL/kg feed with vitamins and binders to reinforce the enteric mucosal barrier.

Step 3: Broadcast Next Converter @ 1.5 Litres/acre to prevent nitrogenous metabolites from aggravating physiological stress.

Prescribed Clinical Formulation100% Antibiotic-Free • CAA Approved

Next Viro Nill & Next Gut Co-Administration

Manufactured under sterile conditions in New Autonagar, Vijayawada, Andhra Pradesh. Directly calibrated against the clinical protocol outlined above.

Direct Factory Price:₹1,199 (1L) / ₹5,000 (5L Can)
View Specs & OrderCalculate Pond Dosage
Related Knowledge Assets & Diagnostic Engines
Pathology Monograph:Running Mortality Syndrome (RMS)View full PCR targets & histology →Clinical Tools:Aqua Calculators SuiteAmmonia TAN, Biomass, Aeration math →Diagnostic AI:Pond Doctor EngineInteractive symptom prescription →
తెలుగు ప్రాంతీయ కీలక పదాలు (Telugu Aqua Search Keywords):
రొయ్యల రోజువారీ మరణాలురన్నింగ్ మోర్టాలిటీ నివారణచెరువులో రొయ్యలు చనిపోవడంనెక్స్ట్ విరో నిల్ మందు
Frequently Asked Questions
Does changing pond water stop RMS?

No. Pumping un-chlorinated inlet creek water usually introduces fresh viral vectors or wild crustacean carriers, aggravating the mortality rate.

Scientific Citations & Institutional Regulatory References:
  1. Alavandi, S. V., et al. (2019). Investigation of Running Mortality Syndrome (RMS) in Litopenaeus vannamei culture in India. Aquaculture Research.